Table 1.
Genes with Consistent Change in Expression (≥1.7-fold) at the Early Timepoint of Two Rodent Models of Experimental Retinal Neovascularization
| Change (I-Fold) | Step-up P-value | ||
|---|---|---|---|
| Rat genes (P15), of a total of 43 | |||
| EGL nine homolog 3 (C. elegans) | Egln3 | 2.5 | 0.008 |
| Chemokine (C-X-C motif) receptor 4 | Cxcr4 | 2.4 | 0.049 |
| Glypican 2 (cerebroglycan) | Gpc2 | 1.9 | 0.036 |
| Pro-melanin-concentrating hormone | Pmch | 1.8 | 0.036 |
| Claudin 5 | Cldn5 | −3.2 | 0.008 |
| Proteoglycan peptide core protein | Pgsg | −2.1 | 0.016 |
| EGF, latrophilin and seven transmembrane domain containing 1 | Elid1 | −2.1 | 0.008 |
| Endothelial-specific receptor tyrosine kinase | Tek | −2 | 0.047 |
| von Willebrand factor | Vwf | −1.9 | 0.008 |
| Vitronectin | Vln | −1.9 | 0.010 |
| Tetraspanin 8 | Tspan8 | −1.9 | 0.049 |
| G protein-coupled receptor 116 | Gpr116 | −1.9 | 0.033 |
| MAM domain containing 2 | Mamdc2 | −1.8 | 0.021 |
| SRY-box containing gene 18 | Sox18 | −1.8 | 0.049 |
| cAMP responsive element binding protein-like 2 | Crebl2 | −1.7 | 0.049 |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | Abcc9 | −1.7 | 0.008 |
| Solute carrier family 39 (iron-regulated transporter), member 1 | Slc40a1 | −1.7 | 0.048 |
| Angiotensin receptor-like I | Agtrl1 | −1.7 | 0.049 |
| Mouse genes (PI3), of a total of 43 | |||
| Transglutaminase 2, C polypeptide | Tgm2 | 5.4 | 0.035 |
| NADH dehydrogenase (ubiquinone) I alpha subcomplex, 4-like 2 | Ndufa412 | 5.3 | 0.005 |
| Metallothionein 2 | Mt2 | 3.7 | 0.038 |
| Adrenomedullin | Adm | 3.5 | 0.035 |
| EGL nine homolog 3 (C. elegans) | Egln3 | 3.5 | 0.036 |
| Tubulin, beta 6 | Tubb6 | 2.8 | 0.041 |
| Selenium binding protein 1 | Setenbpl | 2.7 | 0.038 |
| Centrosomal protein 55 | Cep55 | 2.5 | 0.038 |
| Cell division cycle 2 homolog A (S. pombe) | Cdc2a | 2.4 | 0.044 |
| BCL2/adenovirus EIB interacting protein 1, NIP3 | Bnip3 | 2.3 | 0.003 |
| Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | Mthfdll | 2.3 | 0.038 |
| Histocompatibility 2, K1, K region | H2-K1 | 2.2 | 0.047 |
| Adenylate kinase 3 alpha-like I | Ak311 | 2.2 | 0.003 |
| Phosphalidylinositol-specific phospholipase C, X domain containing 1 | Plcxdl | 2.1 | 0.049 |
| Galactokinase 1 | Galk1 | 1.9 | 0.046 |
| Phosphofructokinase, platelet | Pfkp | 1.9 | 0.039 |
| Harvey rat sarcoma oncogene, subgroup R | Rras | 1.8 | 0.049 |
| EROI-like (S. cerevisiae) | Eroll | 1.8 | 0.038 |
| Nucleolar and spindle associated protein 1 | Nusap1 | 1.8 | 0.034 |
| EGL nine homolog 1 (C. elegans) | Egln1 | 1.8 | 0.035 |
| Solute carrier family 14 (urea transporter), member 1 | Slcl4a1 | 1.7 | 0.036 |
| Procollagen, type II, alpha 1 | Col2a1 | 1.7 | 0.021 |
| HIG1 domain family, member 1A | Higdla | 1.7 | 0.013 |
| Pyruvate dehydrogenase kinase, isoenzyme 1 | Pdkl | 1.7 | 0.021 |
| Vascular endothelial growth factor A | Vegfa | 1.7 | 0.038 |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | Abcc9 | −3.3 | 0.042 |
| Potassium inwardly-rectifying channel, subfamily J, member 8 | Kenj8 | −3.2 | 0.034 |
| Solute carrier organic anion transporter family, member Ic1 | Stcolcl | −2.3 | 0.044 |
| Aquaporin 4 | Aqp4 | −1.90948 | 0.038 |
| Ecotropic viral integration site I | Evil | −1.70382 | 0.038 |