Table 6.

Biological Pathways Identified from Comparative Analysis of Gene Expression between Early and Late Time Points of OIR in Both Rodent Models (P < 0.01)

Name of Pathway	Representative Genes in Pathway Identified in Microarrays
14-3-3-mediated signaling	MAPKI, PIK3RI, MAPT, HRAS, KRAS, MAP3K, PLCH2, PLCDLPLCD3, JUN, TUBA8, PLCBI, GFAP, GSK3B, YWHAQ, PIK3R2, PRKCA, TUBB3, YWHAG, YWHAE, TNFRSFIA, YWHAB, RRAS, GRB2, TUBB2A, YWHAZ, MAPK8, MAPK6, MAPK9, BAX, PLCI.L2, PIK 3R3, FOS, PLCB4, TUBAIA, FOXOI, PRKCD, PLCG2, YAPLPRKCH, PIK3CD, MAPK7, SNCA, PRKCB
Axonal guidance signaling	DPYSL2, RAC2, BMP4, PIK3RI, HRAS, KRAS, NCKI, ADAM8, NCK2, GNBI, EPHBI, PAKI, BAIAP2, ABLIM3, FIGF, PLCBI, GNAI3, WNTSB, GNG12, EFNA2, CFLI, KALRN, RRAS, SEMA5A, LICAM. MYL9, DOCKI, SRGAP3, ARHGEF6, KLK2, GNB2, RTN4, PAK7, PIK3CD, MAPK7, GNG2.WNT1, GNAL, NRPI, FYN, LRRC4C, RGS3, ARPCIB, BDNF, ARHGEF7, PLXNA2, GNAI4, FZDI, ABLIMI, SEMA6C,
CCR3 signaling in eosinophils	MAPKI, PIK3RI, GNB5, HRAS, KRAS, LIMK2, ROCK2, MYLK, GNBI, PAKI, GNB3, PLCBI, PPPICA, GNG12, CALMI, CFLLITPR2, RRAS, GNG3, ITPRI, PIK3R3, PRKCD, CFL2, JMID7-PLA2G4B, GNB2, PIK3CD, PAK7, PRKCH, MAPK7, GNG2, OPNISW, CAMK4, MAPK11, GNG11, PIK3R2, GNG4, PRKCA, PAK2, PAK6, GNAI1, MAPK6, CCL11, GNG5, GNA12, PLA2G4A, GNAS, PLCB4, MAPKI4, PAK3, PRKCB
CREB signaling in neurons	POLR2F, POLR2D, MAPKI, GRM3, ADCY4, PIK3R1, GNB5, HRAS, KRAS, PLCH2, GRIA4, GNBI, PLCD3, GNB3, GNATI, ADCY5, PLCBI, GNA13, GNGI2, GRIK1, CALM1, ITPR2, RRAS, CREB3, CREBBP, GRIA2, GNG3, ITPRI, PLCL2, PIK3R3, GRM7, POL CG2, PRKCD, GNAOI, GNB2, PIK3CD, PRKCH, GNG2, MAPK7, POLR2I, GNAL, OPNISW, CAMK2G, CAMK4, POLR2J, GNAI4, PLCDI, SHCI, GNGI1.
CXCR4 Signaling	MAPK1, ADCY4, PIK3RI, GNB5, HRAS, KRAS, GNBI, ROCK2, PAKI, MLCI, GNB3, GNATI, ADCYS, PLCBI, MYL4, GNA13, GNGI2, RND2, ITPR2, RRAS, RHOJ, ITPRI, GNG3, MYL9, PIK3R3, DOCKI, PRKCD, GNAOI, GNB2, PIK3CD, PRKCH, PAK7, GNG2, MAPK7, G NAL, FNBPI, OPNISW, GNAI4, GNGII, JUN, RHOTI, GNAT2, PIK3R2, GNG4, PRKCA, PXN, PAK2, PAK6, RHOC, EGRI, GNAII, MAPK8. MAPK6, GNAQMAPK9, GNG5, GNAI2MYL9, GNAS, FOS, RHOV, PLCB4, PAK3, CXCL12, LYN,
Ephrin receptor signaling	RAC2, MAPKI, EPHB2, GNB5, HRAS, LIMK2, KRAS, NCKI, GNBI, ROCK2, NCK2, PAKI, EPHBI, GNB3, GNATI, FIGF, GNAI3, EFNB3, GNG12, EPHA7, EFNA2, KALRN, CFLI, RRAS, CREB3, GNG3, STAT3, RAC3, PDGFB, SDCBP, CFL2, GNAOI, GNB2, P AK7, GNG2, MAPK7, GNAL, FYN, RGS3, ARPCIB, GNAI4, JAK2, PGF, EFNB2, SHCLGNG11, ACTR3, WASL, SORBSI, GNAT2.GNG4, ITGBI, GRIN2B, PXN, PAK2, PAK6, GRB2, GNA11, MAPK6.
Adrenergic signaling	CAMK4, MAPK1, ADCY4, GNB5, HRAS, KRAS, GNBI, GYSI, GNB3, GNG11, ADCY5, HLA-B, GNG4, GNG12, PRKCA, CALMI, PRAS, ITPR2, GNAQ, MAPK6, SLC8A3, GNA11, GNG3, ITPRI, GNG5, GNAI2, ADRA2A, GNAS, PYGM, PRKAR2B, PRKCD, PLCG2, GNB2, PRKCH, MAPK7, GNG2, ADCY7, OPNISW, PRKCB
Melatonin signaling	CAMK4, MAPK1, PLCH2, PLCDI, PLCD3, RORA, PLCBI, CALM1, CAMK2B, PRKCA, GNA11, MAPK6, GNAQ. RORC, PLCL2, GNA12, PLCB4, PRKAR2B, PLCG2, PRKCD, GNAOI, PRKCH, MAP2K3, MAPK7, RORB, OPNISW, MAP2K5, PRKCB, CAMK2G
Reelin signaling in neurons	PAFAHIB2, FYN, APOE, PIK3RI, MAPT, DABI, APP, CDK5RI, YESI, CDK5, HCK, ARHGEF2, GSK3B, ARHGEF3, PIK3R2, ITGBI, ARHGEFI2, CNRI, MAPK8IP2, MAPK8, ITGA6, MAPK9, MAPK8IPI, ITGB3, PIK3R3, APBBI, ITGB2, ARHGEF5, ARHGEF10, ARHGEF6, LYN, ITGAI, LRP8, PIK3CD, PAFAHIBI, DCX, PAFAHIB3
Synaptic long-tern depression	MAPKI, PPP2CA, GRM3, ADCY4, HRAS, KRAS, PRKG2, PLA2G2C, GNATI, LCAT, ADCY5, PPMIJ, RYR3, PLCBI, GNA13, GUCYIA3, ITPR2, RRAS, GRIA2, YWHAZ, C7ORF16, ITPRI, GRM7, PPP2R3A, PRKCD, GNAOI, PRKCH, MAPK7, GNAL, PPP2R2A GNA14, PRDX6, GRIDI, IGFI, GNAT2, IGFIR, PPP2R2C, PRKCA, PPP2R5C, PPP2R5D, GNAQ, GNAII, MAPK6, PPP2R5A, LAMB2, GNAI2, GRN, PLA2G4A, GNAS, PLCB4, LYN, PPP2RSE.
Tight junction signaling	TGFBRI, PPP2CA, JAM2, MLLT4, CLDN7, PARD6A, OCLN, TGFBR2, MYLK, MPDZ, TGFBI, PPMLI, CGN, MYL4, ACTAI, CSTFLT1, TIAMI, TJP2, MYL9, CLDN23, PPP2R3A, CDK4, PRKCH, CPSF2, RELA, PPP2R2A, PVRL3, CTNNAI, NFKBI, JUN, CEBPA, TGF B2, PPP2R2C, ARHGEF2, STX4, VCL, TNFRSFIB, ACTCI, PPP2R5C, TJPI, TNFRSFIA, PPP2R5D, CASK, ACTGI, PPP2R5A, FIIR, EPB41, FOS, PRKAR2B, CLDN5, CLDNI NUDT21.