Table.
Reference | Diagnostic strategy | No of patients | No (%) with deep vein thrombosis | % with venous thromboembolic complications (95% CI) | Mean No of additional ultrasound tests (or venograms*) required per initially referred patient |
---|---|---|---|---|---|
Sluzewski et al5 | Ultrasonography at days 1, 2, and 7 | 118 | 32 (27) | 1.3 (0 to 3.9) | 1.3 |
Heijboer et al4 | Ultrasonography at days 1, 2, and 8 | 491 | 103 (21) | 1.5 (0.3 to 2.8) | 1.6 |
Cogo et al7 | Ultrasonography at days 1 and 7 | 1702 | 408 (24) | 0.7 (0.3 to 1.2) | 0.8 |
Birdwell et al6 | Ultrasonography at days 1 and 5-7 | 405 | 69 (17) | 0.6 (0.1 to 2.1) | 0.8 |
Wells et al14 | Ultrasonography at day 1 with clinical score† | 593 | 95 (16) | 0.6 (0.1 to 1.8) | 0.3* |
Present study | Ultrasonography at day 1, if normal: d-dimer; repeat ultrasound at 1 week if d-dimer positive | 946 | 265 (28) | 0.4 (0.0 to 0.9) | 0.1 |
Includes venography in 5.6% of patients.
Low clinical score: normal ultrasonogram (stop), abnormal ultrasonogram (venography); moderate clinical score: normal ultrasonogram (repeat ultrasonography at 1 week), abnormal ultrasonogram (treatment); high clinical score: normal ultrasonogram (venography), abnormal ultrasonogram (treatment).