Table 1.
Daptomycin |
Linezolid |
Vancomycin |
Quinupristin/dalfopristin |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Study year | Region | Source of isolates | Enterococcus species | No. of isolates | MIC90 | % susceptibility | MIC90 | % susceptibility | MIC90 | % susceptibility | MIC90 | % susceptibility | Reference |
2006 | USA | bacteraemia, wound or other infections | enterococci | 547 | 2 | 99.8 | 2 | 97.4 | >16 | 71.7 | >2 | 31.1 | 8 |
2004–05 | Europe | various infection types | VSE | 484 | 4 | 100 | 2 | 99.8 | 0.5 | 99.8 | ND | ND | 9 |
VRE | 195 | 4 | 100 | 2 | 100 | ≥64 | 21.7 | ND | ND | ||||
2007 | Europe | various infection types | VSE | 542 | 4 | 100 | 2 | 95.4 | 0.5 | 100 | ND | ND | 9 |
VRE | 187 | 4 | 100 | 2 | 95.7 | ≥64 | 21.4 | ND | ND | ||||
2005–07 | Europe | bloodstream, skin or other infections | VSE | 15 | |||||||||
E. faecium | 853 | 2 | 100 | 2 | 99.8 | 1 | 100 | >2 | 70.6 | ||||
E. faecalis | 2133 | 1 | 100 | 2 | 100 | 2 | 100 | >2 | 0.9 | ||||
VRE | |||||||||||||
E. faecium | 267 | 2 | 100 | 2 | 99.3 | >16 | 0 | >2 | 78.3 | ||||
E. faecalis | 18 | 1 | 100 | 2 | 100 | >16 | 0 | >2 | 0 | ||||
2002–05 | USA/Canada | various infection types | VSE | 3336 | 2 | 99.9 | 2 | 99.8 | ND | ND | >2 | 11.2 | 14 |
VRE | 1560 | 4 | 99.4 | 2 | 98.5 | ND | ND | 2 | 86.9 | ||||
2005–08 | Europe | bloodstream infections | vancomycin-resistant E. faecium | 134 | 2 | 99.3 | 2 | 98.5 | ND | ND | >2 | 73.1 | 16 |
2005–06 | Canada | various infection types in ICU patients | E. faecalis | 91 | 1 | 100 | 2 | 92.3 | 2 | 97.8 | ND | ND | 17 |
E. faecium | 29 | 2 | 100 | 8 | 34.5 | >64 | 72.4 | ND | ND | ||||
VRE | 17 | 1 | 100 | 4 | 64.7 | >64 | 0 | ND | ND | ||||
other enterococci | 135 | 1 | 100 | 2 | 97.2 | 2 | 94.7 | ND | ND | ||||
2007–08 | USA/Korea | blood or skin infections | E. faecalis (USA/Korea) | 455 | 2 | 100 | 2 | 96.9 | 4 | 96.0 | 32 | 0.9 | 13 |
E. faecium (Korea) | 184 | 4 | 100 | 2 | 95.7 | >128 | 73.4 | 4 | 78.8 | ||||
E. faecium (USA) | 205 | 4 | 98.5 | 4 | 85.9 | >128 | 20.0 | 2 | 71.7 |
ICU, intensive care unit; ND, not determined; VRE, vancomycin-resistant enterococci; VSE, vancomycin-susceptible enterococci.
All MIC data were measured using broth microdilution.