Figure 4.

Efficacy of bacterial treatment of implanted cancer in mice. A. Survival (Kaplan-Meier) curves of BALB/c mice bearing s.c. 4T1 tumours (50-100 mm³). Symbols: untreated mice administered saline (control; black circle); SL7838-treated mice (black square); SL7842-treated mice (black triangle) (n = 5 animals/group) (*p <0.015, **p < 0.003). Bacteria (10⁵ CFU) were administered intratumourally at the start of the experiment. B. Tumour burden measured at indicated time points using caliper. Symbols as above. T-tests *p < 0.064, **p < 0.022, ***p < 0.035