Figure 3.

Pathway analysis of major gene products affected by virulent infection. A sub-network of the response network from Figure 2 reveals interactions between the major gene products affected by virulent infections. This network is in accordance with Figure 5 of Djavani et al. (2007) [16]. In contrast to Djavani et al., PTGS2 and IL1RL1 (not shown: as well as IL1R1 and IL1R2) are up-regulated. EGR1, EGR2, FOS, FOSB are transcription factors. PTGS2 encodes prostaglandin-endoperoxide synthase 2, IL1A/B code for interleukin 1 and IL1RL1 belongs to the interleukin 1 receptor family. Color coding is according to Figure 1. Black arrows indicate known connections not realized in this particular response network (see Additional files 5 &6).