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. 2010 May 12;5(5):e10610. doi: 10.1371/journal.pone.0010610

Table 1. Numbers of 1975-1999 Approvals for Neglected Diseases.

Disease Category Trouiller et al. new chemical entities (NCEs) targeting “tropical diseases” and tuberculosis Our Analysis
Our recount of Trouiller et al. NCEs Our tally of G-Finder defined drugs targeting neglected diseases Our tally of G-Finder defined indications targeting neglected diseases
HIV/AIDS* n/a** n/a** 6*** 6
Malaria 4 7 7 7
Tuberculosis 3 12 12 12
Bacterial Pneumonia and Meningitis n/a** n/a** 3 3
Diarrheal Diseases n/a** n/a** 2 4
Kinetoplastids 5 2 2 2
Buruli Ulcer n/a** 0 0 1
Dengue Fever 0 0 0 0
Helminths 4 9 9 16
Leprosy 0 2 2 2
Trachoma n/a** n/a** 1 1
Rheumatic Fever n/a** n/a** 1 1
Typhoid and Paratyphoid Fever n/a** n/a** 1 1
Total Approvals 16 32 46 56
Percentage on Essential Drug List 94% 85% 85% 82%

*In their analysis, Trouiller et al. included 26 HIV drugs-20 anti-virals and 6 drugs for “opportunistic diseases”-but as a separate (non-neglected) disease category.

**Disease categories Trouiller et al. did not include in their analysis.