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. 2010 May 12;5(5):e10600. doi: 10.1371/journal.pone.0010600

Figure 3. Evolutionary conservation of the Hoxa5-Hoxa7 genomic region among animal species.

Figure 3

(A) The mouse sequence of the Hoxa5-Hoxa7 loci was compared to that of rat, human, orangutan, dog, horse, opossum, chicken, xenopus tropicalis, stickleback, zebrafish, fugu and medaka using the UCSC genome browser. The regions with vertical lines indicate conserved sequences. In addition to Hox exons, the DNA regions located upstream the Hoxa5 distal transcription start sites at positions −4409 bp (D1) and −8905 bp (D2) show high homology between divergent species (boxes), suggesting the presence of evolutionary conserved important regulatory DNA elements. (B) Alignment of the nucleotides of a 160-bp DNA fragment from the D2 region indicates the presence of a consensus TATA box and a transcription initiation site (boxes) in most species.