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. 2010 May 12;5(5):e10600. doi: 10.1371/journal.pone.0010600

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Coulombe et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Genomic organization of the Hoxa5, Hoxa6 and Hoxa7 genes along the cluster. Probes a, b, c and d used for northern blot analyses and whole-mount in situ hybridization are indicated below. (B) Northern blots of polyA⁺ RNA extracted from e12.5 wild-type and Hoxa5 ^−/− embryos were hybridized with each probe. (C) Whole-mount in situ hybridization of e12.5 wild-type embryos with probes a-d. Anterior limits of expression are indicated for the neural tube (white arrowheads) and the prevertebral column (black arrows). The different profiles reveal the specific expression of the transcripts: probe a allows to identify the structures that exclusively express the 1.8 kb transcript. Theses structures include the pv3-pv10 axial domain and the pectoral girdle (black arrowhead). The larger transcripts are expressed in more posterior structures than the 1.8 kb transcript. B, BglII; H, HindIII; K, KpnI; RI, EcoRI; Xh, XhoI.