Figure 6. Restricted spatial distribution of HOXA5 protein along the antero-posterior axis and in the respiratory and digestive tracts.
HOXA5 immunoreactivity is detected in the pv3-pv10 region of the prevertebral column (pvc) of e12.5 wild-type mouse embryos by immunofluorescence (bracket; A). No immunoreactivity is seen in the Hoxa5 −/− specimens confirming the absence of the protein in the null mutant mouse line (B). HOXA5 is also detected in the mesenchymal component of the trachea (C), lung (D), stomach (E) and intestine (F) of e12.5 mouse embryo. e, epithelium; m, mesenchyme.