Table 1.

Single marker TDT (TRANSMIT) for 22 SNPs within the CAPON gene

SNP	Numbera	allele	allele frequencyb	O	E	Var(O-E)	χ2 (1 d.f.)	p value	bootstrap p valuec
rs12090585	1	G	0.667	132	132.98	19.558	0.0487	0.83	0.82
		A	0.333	68	67.024
rs11579080	2	G	0.623	110	109.87	13.812	0.0012	0.97	0.97
		T	0.377	64	64.129
rs1572495	3	G	0.907	180	182.74	8.5861	0.8728	0.35	0.40
		A	0.093	24	21.263
rs1538018	4	G	0.650	146	142.31	18.396	0.7392	0.39	0.39
		C	0.350	60	63.688
rs945713	5	G	0.470	120	109.93	18.947	5.3500	0.021	0.011
		A	0.530	82	92.068
rs1415263	7	C	0.478	87	97.35	19.523	5.4866	0.019	0.015
		T	0.522	117	106.65
rs3924139	8	C	0.426	95	105.48	18.506	5.9341	0.015	0.007
		T	0.574	107	96.521
rs4592244	9	G	0.426	95	105.48	18.506	5.9341	0.015	0.007
		A	0.574	107	96.521
rs4657179	10	G	0.802	164	165.42	13.308	0.1518	0.70	0.70
		T	0.198	40	38.579
rs4145621	11	C	0.570	138	126.19	18.856	7.3991	0.007	0.004
		T	0.430	64	75.812
rs6680461	13	T	0.740	136	144.44	15.679	4.5391	0.033	0.028
		G	0.260	68	59.564
rs4657181	14	A	0.567	143	131.54	19.618	6.6972	0.010	0.006
		T	0.433	63	74.462
rs10800405	15	C	0.724	132	139.15	15.149	3.3715	0.07	0.05
		G	0.276	66	58.853
rs2661818	16	C	0.651	128	124.71	16.631	0.6498	0.42	0.39
		G	0.349	62	65.287
rs3751284	17	C	0.638	105	114.27	20.327	4.2276	0.040	0.019
		T	0.362	95	85.73
rs1504430	18	C	0.681	129	134.41	19.001	1.5430	0.21	0.25
		T	0.319	75	69.585
rs17468951	19	A	0.639	139	136.23	18.138	0.4228	0.52	0.54
		G	0.361	65	67.769
rs12122048	20	G	0.633	138	135.1	17.474	0.4817	0.49	0.47
		A	0.367	64	66.901
rs905720	21	C	0.696	143	139.31	16.922	0.8057	0.37	0.39
		T	0.304	59	62.692
rs348624	22	C	0.845	171	171.12	11.231	0.0013	0.97	0.98
		T	0.155	33	32.877
rs1123005	23	A	0.854	169	173.3	11.254	1.6394	0.20	0.28
		A	0.718	55	56.138
rs11806859	24	G	0.282	147	145.86	15.976	0.0810	0.78	0.80
		A	0.718	55	56.138

Nominally significant χ² and p values are italicized and bold. Markers belonging to LD regions 1 (top) and 2 (bottom) are shaded.

O = observed transmissions; E = expected transmissions; d.f. = degree of freedom.

^aSNP number as in figure 1

^bin untransmitted chromosomes

^cbased on 1000 bootstrap samples.