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. Author manuscript; available in PMC: 2011 May 12.
Published in final edited form as: Chem Rev. 2010 May 12;110(5):2921–2959. doi: 10.1021/cr900232t

Table 5.

Manganese chelate properties - effect on relaxivity due to binding of Mn2+ complexes to HAS.481–482

Relaxivity (mM−1s−1)(20 MHz, 298 K, pH 7.4) kex298 (s−1) at 298 K
Unbound Bound to HSA
EDTA(BOM) 3.6 ± 0.2 55.3 ± 2.5 0.93 × 108
EDTA(BOM)2 4.3 ± 0.2 48.0 ± 2.3 1.3 × 108
DO3A(BOM)3 1.6 ± 0.1 8.1 ± 0.4 No coordinated water
L1 5.8 (37°C) 48 (37°C) 2.3 ± 0.9 × 108