Table 4.
ER-Stress-Responsive Genes Associated with Disease Susceptibility
| Disease | Susceptibility Genes Identified in GWAS that Respond to ER Stress |
|---|---|
| Acute lymphoblastic leukemia | ARID5B, ZNF230 |
| AIDS | TGFBRAP1, LTB, MICB, TNF |
| Alzheimer disease | CLU, CR1, FAM113B, PICALM, RFC3, TOMM40, SASH1 |
| Amyotrophic lateral sclerosis | B4GALT6, C9orf72, CSNK1G3, ITPR2, RBMS1, SELL, SLC39A11, ZNF746 |
| Bipolar disorder | CTNNA2, DCTN5, PALB2, MCTP1 |
| HDL cholesterol | CTCF, FADS1, NR1H3, MMAB, MVK, TTC39B |
| Multiple sclerosis | ASAP1, C1GALT1, CD40, CD58, CENPC1, HLA-B, IL12A, IRF8, JAR1D2, KIF1B, METTL1, MPHOSPH9, PTGER4, RAB38, RFK, RPL5, SLC25A36, TNFRSF1A, WDR7, ZMIZ1 |
| Parkinson disease | AAK1, ATF6, PRRG4, QSER1 |
| Rheumatoid arthritis | REL, TRAF1, TNFRSF14 |
| Systemic lupus erythematosus | BLK, ETS1, HIC2, IKZF1, IRF5, PXK, RASGRP3, TNIP1, UBE2L3 |
| Type 1 diabetes | C12orf30, C6orf173, CD69, CDK2, CTSH, HLA-E, IFIH1, IKZF4, IL10, PGM1, PHTF1, PTPN2, RAB5B, SUOX |
| Type 2 diabetes | CAMK1D, CDC123, NOTCH2, THADA, VEGFA, IRS1, WFS1 |