Table 3.
Multiple Regression Analysis of Adult Stature in Three Finnish Cohorts Evaluating Marker-Marker and Marker-Sex Interactions
| Independent Variable | Beta | SE | p Value |
|---|---|---|---|
| rs7759938 | 0.10523 | 0.02986 | 0.000427 |
| rs314277 | −0.16806 | 0.07567 | 0.026377 |
| SEX | −0.65858 | 0.02893 | <2 × 10−16 |
| rs7759938 × rs314277 interaction | 0.04167 | 0.04989 | 0.403553 |
| rs7759938 × SEX interaction | −0.07596 | 0.04143 | 0.066754 |
| rs314277 × SEX interaction | 0.29371 | 0.10412 | 0.004802 |
| rs7759938 × rs314277 × SEX interaction | −0.07654 | 0.06932 | 0.269571 |
The regression analysis was run with cohort-specific Z scores as the dependent variable in Northern Finland Birth Cohort 1966, Helsinki Birth Cohort Study, and Health 2000; n = 8821. Markers rs7759938 and rs314277 and sex, in addition to marker and sex interaction, were included in the regression model. In H2000, adult height was adjusted for age, and the individual scores were obtained from the first dimensions of multidimensional scaling IBS analysis of genotypes generated with Illumina 610 Bead Chips prior to the multiple regression analysis. The AA, AG, and GG genotypes at marker locus rs7759938 were coded as 0, 1, and 2; the CC, CA, and AA genotypes at rs314277 were coded as 0, 1, and 2; and male and female sex were coded as 0 and 1.