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. Author manuscript; available in PMC: 2010 May 13.
Published in final edited form as: J Med Chem. 2008 Nov 27;51(22):7154–7160. doi: 10.1021/jm800668u

Figure 6.

Figure 6

Sal-AMS (1) docked in the MbtA homology model. The protein is represented as a ribbon diagram, N-terminal red, C-terminal blue. The ligand is shown in a tube representation and colored by element. The green surfaces expose volumes that, when filled with hydrophobic groups, improve potency and specificity. The larger of the two is the C-2 cleft (accessed by compounds 25–31) while the smaller is the N-6 pocket (accessed by compounds 16–24). Filling the yellow volumes results in a reduction in potency.