Table 3.
Brain regions where activity correlated significantly with clinical measures: A. bladder diary reports of daytime urge incontinence episodes (p < 0.05, r > 0.48); B. pad measurements of daytime urine leakage (p < 0.05, r>0.48); and C. psychological burden measured by Urge Impact Scale (URIS-24) (p < 0.01, r > 0.63).
| Region | Coordinates | T-Value | Z-Value | ||
|---|---|---|---|---|---|
| x | y | z | |||
| A. (daytime urge incontinence episodes) | |||||
| Inferior Frontal Gyrus (BA47) | 34 | 16 | −12 | 8.59 | 4.65 † |
| Lentiform Nucleus | 30 | −4 | 10 | 8.54 | 4.63 |
| Rostral Anterior Cingulate Gyrus (BA24/32) | −12 | 38 | 12 | 7.55 | 4.39 |
| Subgenual Anterior Cingulate Gyrus (BA24/32) | −8 | 24 | −4 | 4.67 | 3.39 |
| Middle Frontal Gyrus (BA11/10) | −28 | 40 | −14 | 7.13 | 4.27 |
| −26 | 56 | 10 | 4.51 | 3.32 | |
| 26 | 54 | −12 | 4.31 | 3.23 | |
| Medial Frontal Gyrus (BA10) | −8 | 52 | 10 | 3.91 | 3.03 |
| 6 | 40 | −8 | 3.55 | 2.84 | |
| Insula (BA13) | 46 | 0 | 2 | 3.95 | 3.05 |
| Parietal Lobe (BA40) | 34 | −46 | 32 | 5.21 | 3.62 |
| Parahippocampal Gyrus (BA34) | 12 | −12 | −18 | 3.50 | 2.80 |
| Transverse Temporal Gyrus (BA41) | 46 | −30 | 12 | 3.34 | 2.71 |
| Middle Temporal Gyrus (BA21) | −46 | 10 | −30 | 5.71 | 3.60 |
| Posterior Cingulate Gyrus (BA31) | −10 | −40 | 36 | 3.80 | 2.97 |
| Cuneus (BA19) | −6 | −94 | 24 | 3.48 | 2.79 |
| Dorsal Anterior Cingulate Gyrus (BA24) | −8 | −6 | 46 | 2.92 | 2.47 |
| B. (daytime urine leakage) | |||||
| Inferior Frontal Gyrus (BA47) | 22 | 22 | −14 | 3.53 | 2.82 |
| Subgenual Anterior Cingulate Gyrus (BA24/32) | 4 | 24 | −10 | 3.18 | 2.62 |
| Rostral Anterior Cingulate Gyrus (BA24/32) | −6 | 38 | 16 | 2.90 | 2.44 |
| Putamen | 22 | 2 | 12 | 3.03 | 2.53 |
| Medial Frontal Gyrus (BA9, BA10) | −10 | 40 | 18 | 2.99 | 2.50 |
| −8 | 46 | 12 | 2.88 | 2.43 | |
| Insula (BA13) | 40 | 12 | 0 | 3.71 | 2.92 |
| Posterior Cingulate Gyrus (BA31) | −10 | −38 | 42 | 3.38 | 2.73 |
| Cuneus (BA19) | −8 | −92 | 24 | 5.44 | 3.71 |
| Dorsal Anterior Cingulate Gyrus (BA24) | −12 | −4 | 50 | 3.13 | 2.59 |
| C. (psychological burden) | |||||
| Precuneus (BA7) | −18 | −64 | 28 | 6.45 | 4.06 |
| 0 | −50 | 38 | 6.40 | 4.05 | |
| −4 | −72 | 48 | 4.91 | 3.50 | |
| Superior Temporal Gyrus (BA39/13) | 50 | −54 | 28 | 6.16 | 3.97 |
| 40 | −48 | 16 | 5.81 | 3.85 | |
| Supramarginal Gyrus (BA40) | 52 | −48 | 34 | 5.52 | 3.74 |
| Insula (BA13) | −34 | −6 | 16 | 4.94 | 3.51 |
| Transverse Gyrus (BA41) | −36 | −36 | 10 | 4.61 | 3.37 |
| Posterior Cingulate Gyrus (BA23/31) | 2 | −34 | 28 | 4.74 | 3.42 |
| Cuneus (BA19) | −6 | −82 | 30 | 4.40 | 4.06 |
†
Significant after small volume correction for multiple comparisons at FWE level (P = 0.001) and cluster level (p < 0.01). Note: this location is within the region of interest referred to as insula.