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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2009 Dec 4;48(3):457–467. doi: 10.1016/j.freeradbiomed.2009.11.022

Figure 1. CB2 activation attenuates the cisplatin-induced renal dysfunction; enhanced cisplatin-induced dysfunction in CB2 knockout mice.

Figure 1

Cisplatin induced profound renal dysfunction 72 h after the administration to mice evidenced by increased serum levels of blood urea nitrogen (BUN) and creatinine (Panel A), which were attenuated by CB2 agonist HU-308 treatment (starting from 1.5 hrs before the cisplatin injection and every 24 hours thereafter until the measurements were taken at 72 hours). Starting from 6 hrs after the cisplatin administration HU-308 was still effective, however it lost efficacy when it was administered after the full inflammatory response already developed at 48 or 60 hours (panel B). Results are mean±S.E.M. of n=8-10/group, *P<0.01 vs. vehicle; #P<0.05 vs. cisplatin). The cisplatin-induced renal dysfunction was enhanced in CB2-/- mice compared to CB2+/+ littermates (Panel C). Results are mean±S.E.M. of 6-7 experiments/group *P<0.01 vs. vehicle in CB2+/+ or CB2-/- mice; #P<0.05 vs. cisplatin in CB2+/+ mice.