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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Free Radic Biol Med. 2009 Dec 4;48(3):457–467. doi: 10.1016/j.freeradbiomed.2009.11.022

Figure 8. CB2 activation attenuates the cisplatin-induced increased lipid peroxidation/ROS generation, overexpression of superoxide generating enzymes NOX4(RENOX), NOX2(gp91phox) and NOX1; increased cisplatin-induced ROS generation in CB2 knockout mice.

Figure 8

Cisplatin induced marked increases in lipid peroxidation/ROS generation (HNE and MDA; panela A and B); mRNA expression of NOX4, NOX2 and NOX1 (Panels C-E) in the kidneys 72 h following the administration to mice, which were attenuated by HU-308 treatment (starting from 1.5 hrs before the cisplatin injection, Panels A and B, left). Results are mean±S.E.M. of 5-10 experiments in each group *P<0.01 vs. vehicle; #P<0.05 vs. cisplatin. The cisplatin-induced increased renal NOX1, NOX2 and NOX4 mRNA expression was enhanced in kidneys of CB2-/- mice compared to CB2+/+ littermates (Panels C-E, right). Results are mean±S.E.M. of 6-7 experiments/group *P<0.01 vs. vehicle in CB2+/+ or CB2-/- mice; #P<0.05 vs. cisplatin in CB2+/+ mice.