. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):367–372. doi: 10.1016/j.ijrobp.2009.04.029

Table 1.

Dose Escalation/De-escalation

Dose Level	Radiation Therapy
Dose Level	Original Protocol	Amended Protocol
1	75.25 Gy / 35 fxs (2.15 Gy per fraction)		Cohort 1
2	80.5 Gy / 35 fxs (2.3 Gy per fx) (escalation dose^†)	74 Gy / 37 fxs (2.0 Gy per fx) (de-escalation dose)	Cohort 2 (MTD)
3	79.5 Gy / 30 fxs (2.65 Gy per fx) (escalation dose^†)	70 Gy / 35 fxs (2.0 Gy per fx) (de-escalation dose^‡)
4	75 Gy / 25 fxs (3.0 Gy per fx) (escalation dose^†)	n/a

^†

Amended since dose level 1 was too toxic.

^‡

Unnecessary since dose level 2 was deemed safe.