Table 4.
Non-Hematogic Grade ≥ 3 Toxicities and Hematogic Grade ≥ 4 Toxicities from Table 2
| RX | Case* | Category | Toxicity | Grade |
|---|---|---|---|---|
| Arm 1 | A | Allergy/immunology | Hypersensitivity NOS | 3 |
| Infection/febrile neutropenia | Infection NOS (DLT) | 5 | ||
| Pulmonary | Dyspnea NOS | 3 | ||
| Pneumonitis NOS | 3 | |||
| B | Cardiovascular (general) | Cardiac troponin I increased | 3 | |
| Coagulation | Prothrombin time prolonged | 3 | ||
| Metabolic/laboratory | Hyperglycemia NOS | 3 | ||
| C | Gastrointestinal | Dehydration | 3 | |
| D | Cardiovascular (arrhythmia) | Sinus tachycardia | 3 | |
| Musculoskeletal | Muscle weakness NOS | 3 | ||
| Pain | Pain-other: back pain | 4 | ||
| Myalgia | 3 | |||
| Pulmonary | Pleural effusion | 3 | ||
| E | Pulmonary | Pneumonitis NOS (DLT) | 3 | |
| F | Neurology | Convulsions NOS | 3 | |
| Arm 2 | G | Cardiovascular (general) | Hypotension NOS | 3 |
| Constitutional symptoms | Weight decreased | 3 | ||
| Gastrointestinal | Anorexia | 3 | ||
| Dehydration | 3 | |||
| Neurology | Depression NEC | 3 | ||
| H | Allergy/immunology | Hypersensitivity NOS | 4 | |
| I | Cardiovascular (general) | Thrombosis NOS | 3 | |
| J | Gastrointestinal | Nausea | 3 | |
| Esophagitis NOS (DLT) | 3 | |||
| Dehydration | 3 | |||
| Esophageal spasm | 3 | |||
| Vomiting NOS | 3 | |||
| Infection/febrile neutropenia | Infection with grade 3 or 4 neutropenia | 3 | ||
| Neurology | Tremor NEC | 3 | ||
| K | Coagulation | Prothrombin time prolonged | 3 | |
| Neurology | Syncope | 3 | ||
| Pain | Chest pain | 3 | ||
| Pulmonary | Dyspnea NOS | 3 | ||
| Pneumonitis NOS | 3 | |||
| Hypoxia | 3 | |||
| L | Pain | Bone pain | 3 | |
*
The case numbers of the 12 out of 17 possible patients (listed above) were changed to letters to protect their privacy.