Table 1.

Proinflammatory genes differentially regulated by intermittent hypoxia and sustained hypoxia (4% O₂) compared with normoxia

		IH		SH-4%
Probe ID	Gene Name	Fold Change	q, %	Fold Change	q, %
Genes upregulated by intermittent and sustained hypoxia
GI_4507676-S	Heat shock protein 90 kDa β1 (HSP90-B1)	3.70	<0.10	2.28	<0.10
GI_40254815-S	Heat shock protein 90 kDa, α1 (HSP90-A1)	3.40	<0.10	1.71	<0.10
GI_22027639-S	Histone 2, H2be (HIST2H2BE)	1.89	<0.10	2.07	<0.10
GI_4504252-S	H2A histone family, member X (H2AFX)	1.81	0.289	1.84	<0.10
GI_39812261-S	Histone 1, H3d (HIST1H3D)	1.80	<0.10	1.76	<0.10
GI_4503174-S	Chemokine (C-X-C motif) receptor 4 (CXCR4)	1.70	<0.10	1.94	<0.10
GI_21237796-A	Histone deacetylase 5 (HDAC5), transcript variant 1	1.69	0.162	1.64	0.178
Genes upregulated by intermittent hypoxia only
GI_40317625-S	Thrombospondin 1 (THBS1)	1.86	<0.10	NS
GI_4505564-S	Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), α polypeptide I (P4HA1)	1.82	0.162	NS
GI_23510446-S	Tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34 kDa) (TNFSF4)	1.78	<0.10	NS
GI_19743812-I	Integrin, β1 (fibronectin receptor, β polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1A	1.66	1.656	NS
GI_4505204-S	Matrix metalloproteinase 10 (stromelysin 2) (MMP10)	1.66	0.386	NS
GI_22027623-A	TNF receptor-associated factor 4 (TRAF4), transcript variant 2	1.65	<0.10	NS
GI_14790114-A	Caspase 3, apoptosis-related cysteine protease (CASP3), transcript variant β	1.64	0.162	NS
GI_18379365-S	Zinc metalloproteinase (STE24 homolog, yeast) (ZMPSTE24)	1.61	0.162	NS
GI_19743818-A	Integrin, β1 (fibronectin receptor, β polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1D	1.60	2.136	NS
GI_28610153-S	Interleukin 8 (IL8)	1.57	2.931	NS

IH, intermittent hypoxia; SH-4%, sustained hypoxia (4% O₂); q, false discovery rate; NS, not significant.