HPLC profile of meilingmycins and structure comparison between meilingmycins and avermectin. (A) HPLC profile of meilingmycins. (B) Structures of meilingmycins and avermectin A1a. The carbons of meilingmycins are numbered. The five meilingmycins are different at R1 to R5, and the differences are shown in the table. Meilingmycins A, B, and C contain a furan ring between R4 and R5 and a side chain at R3. No furan ring and side chain are identified in meilingmycins D and E, which are methylated at C-5. mAU, milli-absorbance units.