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. 2010 Mar 26;76(10):3283–3292. doi: 10.1128/AEM.02262-09

FIG. 2.

FIG. 2.

Physical map and gene organization of meilingmycin biosynthetic gene clusters. (A) Physical map of meilingmycin biosynthetic gene clusters. The vertical dashed lines indicate the positions of primers for chromosome walking. The horizontal lines indicate individual cosmid/fosmids, and those shown in pink are sequenced regions, including the 17-kb ClaI fragment from 2G6 and the 8.5-kb SacI fragment from 26H12. (B) Gene organization of meilingmycin biosynthetic gene clusters. ave, avermectin biosynthetic gene cluster (14); mei, meilingmycin biosynthetic gene cluster; red, PKS genes; blue, genes for post-PKS modifications; green, regulatory genes; blank arrows, genes probably not related to meilingmycin biosynthesis. The ORFs boxed with dashed lines are from the previously sequenced 103-kb region.