(A) NTG and (B) MHCPim-wt CSCs cultured in growth media, fixed and immunolabeled with antibodies to Pim (green), c-kit (red) and Topro (blue). MHCPim-wt CSCs show increased Pim expression localized to the cytoplasm. (C) NTG and (d) MHCAkt-nuc CSCs cultured in growth media, fixed and immunolabeled with Myc-tag (green), c-kit (red) and Topro (blue). MHCAkt-nuc CSCs show nuclear-localized myc-tag expression. Scale bar is 40 μm.
CSC: Cardiac stem cell; MHC: Myosin heavy chain; NTG: Nontransgenic.