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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Regen Med. 2009 Nov;4(6):823–833. doi: 10.2217/rme.09.51

Figure 5. Differentiation of cardiac stem cells by exposure to dexamethasone results in loss of transgene expression.

Figure 5

(A) MHCPim-wt CSCs cultured in growth media, fixed and immunolabeled for c-kit (green), Pim (red) and Topro (blue). (B) MHCPim-wt CSCs treated with dexamethasone containing media for 7 days, fixed and immunolabeled for c-kit (green), Pim (red) and Topro (blue) show decreased c-kit as well as Pim expression. (C) MHCAkt-nuc CSCs cultured in growth media, fixed and immunolabeled for c-kit (green), myc-tag (red) and Topro (blue). (D) MHCAkt-nuc CSCs treated with dexamethasone containing media for 7 days, fixed and immunolabeled for c-kit (green), Myc-tag (red) and Topro (blue) show decreased c-kit as well as myc-tag expression. Scale bar is 100 μm.

CSC: Cardiac stem cell.