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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2010 Apr;69(4):356–371. doi: 10.1097/NEN.0b013e3181d53d98

Figure 3.

Figure 3

Hic-5 distribution in Alzheimer disease (AD) hippocampi. Confocal microscopy with Hic-5 (green), nuclei (blue) and β-amyloid, pTau (AT8), or microglia (CD68) (red). Hic-5 was localized to pyramidal neurons, their processes and cores within β-amyloid+ plaques (a–c). Arrow in (a) indicates a beaded process that projects through the plaque in (c). Hic-5 was not contained in neuritic plaque components labeled by AT8 (d–f) but a subset of AT8+ neurofibrillary tangles (NFTs) within pyramidal neurons contain Hic-5 (d–i). Arrow in (g) indicates Hic-5 in a pyramidal neuron that lacks NFTs (g–i). Hic-5 was also located in nuclei of CD68+ microglia within plaques (j–l). Scale bars = 50 µm for all panels.