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Model for direct and indirect role of GH in adipogenesis. GH can act directly on the preadipocyte to influence adipogenesis. The studies in the current report also indicate a novel indirect mode of GH action on the preadipocyte wherein GH acts on the adipose tissue macrophage to decrease IL-1β secretion by the macrophage. IL-1β is a known inhibitor of adipogenesis, and thus, GH’s action on the macrophage serves to enhance adipogenesis.
