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. 2010 Feb 26;151(5):2078–2086. doi: 10.1210/en.2009-0850

Figure 4.

Figure 4

UCP2 controls fat metabolism gene expression profile in white adipose tissue after ghrelin delivery (10 nmol/d for 14 d) via osmotic minipumps. A, Ghrelin significantly increases white adipose tissue SCD1 gene expression in both ucp2−/− and ucp2+/+ ghrelin-treated mice relative to saline controls; however, ucp2−/− ghrelin mice show a further significant increase relative ucp2+/+ ghrelin mice (n = 6–7, P < 0.05). B, Ghrelin significantly increases FAS in white adipose tissue of ghrelin-treated ucp2−/− mice compared with saline controls. No effect of ghrelin was observed in ucp2+/+ mice (n = 6). C, Ghrelin significantly increases white adipose tissue LPL mRNA in both ucp2−/− and ucp2+/+ ghrelin-treated mice relative to saline controls; however, ucp2−/− ghrelin-treated mice show a further significant increase relative ucp2+/+ ghrelin mice (n = 6–7, P < 0.05). D, Ghrelin increases UCP2 mRNA in white adipose tissue (n = 6–7, P < 0.05). E, No effect of ghrelin on ACC was observed in either genotype (n = 6–7, P < 0.05). F, CPT1 was decreased in ghrelin-treated ucp2−/− mice relative to saline-treated ucp2−/− mice. Ghrelin had no significant effect on CPT1 mRNA in ucp2+/+ mice (n = 6, P < 0.05). All data are expressed as mean ± sem. a, Significant with respect to saline controls; b, significant with respect to ucp2+/+ ghrelin.