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. 2010 May 13;5(5):e10627. doi: 10.1371/journal.pone.0010627

Figure 1. Conditions screened for SOD1 fibrillisation.

Figure 1

SOD1 variants with higher stability were able to form fibrils over a wide range of conditions (i.e. number of combinations of pH and denaturant strength) characterized by variation in lag times (wtSOD red square = 10 combinations; G93A light blue square = 6 combinations; G37R green square = 5 combinations; A4V dark blue square = 2 combinations; G85R yellow square = 2 combinations). For the more stable proteins, when incubated in increasing denaturant strength, lag time for fibrils to form is shortened (data not shown).