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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Prostate Cancer Prostatic Dis. 2010 Jan 12;13(2):151–161. doi: 10.1038/pcan.2009.59

Figure 3. Post-freeze viability of prostate cancer cells following integrin function blocking.

Figure 3

Figure 3

The effects of α6, β4, and α6β4 integrin function blocking (40μg/ml) upon freeze response were analyzed using the metabolic indicator, alamarBlue. The AS cell line LNCaP LP (A) exhibited small decreases in cell viability following exposure to integrin function blocking, while α6β4 blocking showed the most significant effect compared to separate subunits. AI LNCaP HP (B) showed a greater decrease in post-freeze viability, while α6β4 integrin function blocking exhibited the greatest effect. These data indicated a differential response between AS and AI cell lines demonstrating that α6β4 integrin function blocking had greater effects on AI cell lines. Data presented represents a minimum of 3 experimental repeats with a intra experimental replication of 8 (N≥3, N≥24)