Fig. 2.

Changes in pain behaviors by pharmacological regulation of spinal GABAergic activity. (A) Mechanical allodynia induced by intrathecal administration of GABA antagonists, bicuculline and phaclofen, in naïve rats. (B) Attenuation of nerve injury-induced mechanical allodynia by GABA agonists, muscimol and baclofen, applied spinally. (C) Reversal of nerve injury-induced mechanical allodynia by intrathecally administered GAT inhibitors, NNC 711 for GAT-1 and SNAP 5114 for GAT-3. 'Pre' and 'N14' indicate 1 day before and 14 days after neuropathic surgery, respectively. ^*p≤0.05, ^**p≤0.001 vs. pre-injection value (One-way repeated measures ANOVA followed by Bonferroni t-test).