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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Kidney Int. 2009 Sep 23;76(11):1137–1141. doi: 10.1038/ki.2009.357

Figure 1. Hepcidin down-regulates ferroportin expression on the cell surface.

Figure 1

Ferroportin (FPN) is expressed on the surface of enterocytes, hepatocytes and tissue macrophages. The binding of hepcidin to FPN leads to its phosphorylation, internalization, and degradation. Low levels of FPN expression reduce iron absorption in the gut, lower iron release from the liver, and prevent iron recycling by tissue macrophages.