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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Kidney Int. 2009 Sep 23;76(11):1137–1141. doi: 10.1038/ki.2009.357

Figure 2. Matriptase-2 domain structure and mutants identified in patients with IRIDA.

Figure 2

Matriptase-2 consists of an N-terminal transmembrane domain (TM), one SEA domain, two CUB domains, three LDL receptor repeats (LDLR), and a C-terminal trypsin-like protease domain. Relative positions of nonsense (♠), missense (◆), splicing junction (♣) and frameshift (♥) mutations identified in patients with IRIDA are indicated.