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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Kidney Int. 2009 Sep 23;76(11):1137–1141. doi: 10.1038/ki.2009.357

Figure 3. Regulation of hepcidin expression by matriptase-2.

Figure 3

Matriptase-2 prevents hepcidin overexpression by degrading hemojuvelin (HJV), which acts as a co-receptor for BMP to promote Hamp gene expression (panel A). In matriptase-2 deficiency (panel B), high levels of HJV enhances the BMP signaling pathway, leading to overexpression of hepcidin. Hepcidin inhibits iron absorption, release and recycling, thereby causing IRIDA.