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Hippocampal hypoxia. A, oxygen tension in the hippocampus drops from an average baseline of 17mmHg to 4mmHg during occlusion of the middle cerebral artery (PbtO2= brain tissue oxygen). B, 3 hours after reperfusion HIF1α protein in the hippocampus is increased over 3 fold (n=3, C=contralateral, I=ipsilateral). C, VegfA transcription as measured by real-time PCR is increased 6 hours after reperfusion.
