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. 2010 Jun;2(6):a001198. doi: 10.1101/cshperspect.a001198

Figure 2.

Figure 2.

Scenario of the p53 family gene evolution. The earliest indication of p53 family genes dates back to invertebrates and unicellular choanoflagellae. Aside from independent gene duplications, such as in sea anemone or mosquitos, the earliest indication for mammalian gene splitting dates back to cartilaginous fishes, with tentative orthologs visible in elephant sharks, and all three mammalian paralogs appearing in bony fishes.