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Lesion progression. PAPP-A KO (solid gray bars) and WT (hatched gray bars) mice in the following order: PAPP-A KO 78, 104, and 130 weeks and WT 78 and 104 weeks (see Table 3). Notes: PAPP-A KO = pregnancy-associated plasma protein-A knockout; WT = wild type; 0 = no abnormalities.
