Table 2.

TDT analysis for the most common FBN3 SNP haplotypes and the SNP haplotypes combined with D19S884 alleles

	Allele frequency	T	Not T	Total	Transmission frequency	TDT χ2	P value
SNP haloptype allelea
A. GACCGA	0.454	117	141	258	0.453	2.23	>0.05
B. AGGCGC	0.278	94	118	212	0.443	2.72	>0.05
C. AGCTAC	0.184	100	60	160	0.625	10.00	0.0016
D. AGGCGA	0.030	21	17	38	0.553	0.42	>0.05
E. AGCTAA	0.021	13	10	23	0.565	0.39	>0.05
All others	0.032
Haloptype allele/D19S884 allele
A/11	0.067	33	41	74	0.446	0.86	>0.05
A/13	0.192	86	81	167	0.515	0.15	>0.05
B/7	0.107	54	54	108	0.500	0	>0.05
B/8	0.027	16	19	35	0.457	0.26	>0.05
B/9	0.092	41	53	94	0.436	1.53	>0.05
C/8	0.138	79	48	127	0.622	7.57	0.0059
C/9	0.025	17	11	28	0.607	1.29	>0.05

T, Number of transmissions in TDT analysis. 

^aOrder of SNPs in haplotype: rs3745393, rs2303169, rs17160147, rs17202517, rs73503752, and rs28525575.