Table 4.
PCOS candidate genes with one or more significant SNP (P ≤ 0.05)
| Gene (Ref.) | SNP ID | Position | Overtransmitted allele | T | Not T | Total T | Transmission frequency | TDT χ2 | P value (nominal) |
|---|---|---|---|---|---|---|---|---|---|
| ACVR2A (7) | rs1364658 | chr2:148324277 | C | 123 | 118 | 241 | 0.510 | 0.10 | >0.05 |
| rs1895694 | chr2:148336215 | T | 227 | 193 | 420 | 0.541 | 2.75 | >0.05 | |
| rs1424941 | chr2:148359587 | T | 156 | 113 | 269 | 0.580 | 6.87 | 0.009 | |
| rs12987286 | chr2:148380037 | T | 120 | 110 | 230 | 0.522 | 0.44 | >0.05 | |
| rs3768688 | chr2:148387570 | G | 189 | 146 | 335 | 0.564 | 5.52 | 0.019 | |
| rs2303392 | chr2:148396896 | C | 119 | 106 | 225 | 0.529 | 0.75 | >0.05 | |
| rs3768686 | chr2:148409245 | T | 229 | 182 | 411 | 0.557 | 5.38 | 0.020 | |
| POMC (7) | rs1042571 | chr2:25237390 | G | 113 | 107 | 220 | 0.514 | 0.16 | >0.05 |
| rs12473543 | chr2:25240684 | T | 181 | 128 | 309 | 0.586 | 9.09 | 0.003 | |
| rs934778 | chr2:25242727 | G | 96 | 88 | 184 | 0.522 | 0.35 | >0.05 | |
| rs1009388 | chr2:25244604 | C | 123 | 119 | 242 | 0.508 | 0.07 | >0.05 | |
| FEM1B (22) | rs10152450 | chr15:66358532 | G | 191 | 239 | 430 | 0.447 | 5.36 | 0.021 |
| rs6494730 | chr15:66371610 | T | 175 | 215 | 390 | 0.449 | 4.10 | 0.043 | |
| Haplotype | G-T | 197 | 238 | 435 | 0.453 | 3.86 | 0.049 | ||
| SGTA (24) | rs2238614 | chr19:2706338 | G | 175 | 134 | 309 | 0.567 | 5.44 | 0.019 |
| rs741103 | chr19:2722640 | T | 140 | 118 | 258 | 0.543 | 1.88 | >0.05 | |
| rs1005556 | chr19:2729542 | G | 181 | 144 | 325 | 0.557 | 4.21 | 0.040 | |
| Haplotype | G-T-G | 216 | 165 | 381 | 0.646 | 7.08 | 0.008 |
T, Number of transmissions in TDT analysis.