Table 3.

The distribution of MTHFR 677C>T, MTHFR 1298A>C, and MTR 2756A>G polymorphisms among mothers of children with acute leukemia

	Controls n	Case mothers
		ALL						AML
		Total ALL		B-cell ALL		T-cell ALL
		n	OR (95% CI)	n	OR (95% CI)	n	OR (95% CI)	n	OR (95% CI)
Total*	378	685		573		54		58
MTHFR (677 C>T)
CC	157 (44.7)	315 (47.1)	1.00	261 (46.7)	1.00	26 (49.1)	1.00	24 (45.3)	1.00
CT	159 (45.2)	277 (41.4)	0.87 (0.66-1.14)	229 (41.0)	0.87 (0.65-1.15)	21 (39.6)	0.80 (0.43-1.48)	24 (45.3)	0.99 (0.54-1.81)
TT	35 (10.0)	77 (11.5)	1.10 (0.70-1.71)	69 (12.3)	1.19 (0.75-1.86)	6 (11.3)	1.04 (0.40-2.70)	5 (9.4)	0.93 (0.33-2.62)
CC versus CT/TT	194 (55.2)	354 (52.9)	0.91 (0.70-1.18)	298 (53.3)	0.92 (0.71-1.21)	27 (50.9)	0.84 (0.47-1.50)	29 (54.6)	0.98 (0.55-1.75)
MTHFR (1298A>C)
AA	157 (44.9)	334 (50.1)	1.00	285 (51.2)	1.00	27 (50.9)	1.00	24 (46.2)	1.00
AC	151 (43.1)	254 (38.1)	0.79 (0.60-1.04)	205 (36.9)	0.75 (0.56-1.00)	24 (45.3)	0.92 (0.51-1.67)	18 (34.6)	0.78 (0.41-1.49)
CC	42 (12.0)	78 (11.8)	0.87 (0.57-1.33)	66 (11.9)	0.87 (0.56-1.34)	2 (3.8)	0.28 (0.06-1.21)	10 (19.2)	1.56 (0.69-3.51)
AA versus AC/CC	193 (55.1)	332 (49.9)	0.81 (0.62-1.05)	231 (48.8)	0.77 (0.59-1.01)	26 (49.1)	0.78 (0.44-1.40)	28 (53.8)	0.95 (0.53-1.70)
MTR 2756 (A>G)
AA	239 (68.3)	429 (65.7)	1.00	358 (64.4)	1.00	35 (66.0)	1.00	31 (57.4)	1.00
AG	97 (27.7)	201 (31.2)	1.15 (0.86-2.50)	168 (30.2)	1.16 (0.86-1.56)	16 (30.2)	1.13 (0.60-2.13)	21 (38.9)	1.67 (0.91-3.05)
GG	14 (4.0)	33 (5.1)	1.31 (0.69-2.50)	30 (5.4)	1.43 (0.74-2.75)	2 (3.8)	0.98 (0.21-4.48)	2 (3.7)	1.10 (0.24-5.08)
AA versus AG/GG	111 (31.7)	234 (36.3)	1.17 (0.89-1.55)	198 (35.6)	1.19 (0.90-1.58)	18 (34.0)	1.11 (0.60-2.04)	23 (42.6)	1.60 (0.89-2.87)

ALL indicates acute lymphoblastic leukemia; AML, acute myeloid leukemia; and OR, odds ratio.

^*Totals include persons for whom a result was not available, and varied between single nucleotide polymorphisms.