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. Author manuscript; available in PMC: 2010 May 14.
Published in final edited form as: Hypertension. 2008 Apr 21;51(6):1512–1518. doi: 10.1161/HYPERTENSIONAHA.107.106088

TABLE 4.

Association Between Measures of Forearm Vasoreactivity and Arterial Stiffness.

Model Vasoreactivity Parameter Pulse Pressure
 Log aPWV
Unadjusted
 Adjusted*
 Unadjusted
 Adjusted*
β±SE P β±SE P ΔR2 β±SE P β±SE P ΔR2
1 Systolic flow velocity, m/s
 Baseline 19.62±4.0 <.0001 13.88±3.67 0.0002 0.04 0.31±0.08 <.0001 0.28±0.06 <.0001 0.04
 Hyperemic 6.94±2.17 0.001 −0.82±2.01 0.68 −0.03±0.04 0.46 −0.15±0.04 <.0001
2 Mean flow velocity, m/s
 Baseline −0.01±0.14 0.96 0.13±0.12 0.27 0.01 −0.002±0.003 0.42 0.002±0.002 0.49 0.02
 Hyperemic −0.06±0.03 0.069 −0.06±0.03 0.045 −0.002±0.001 0.0005 −0.002±0.001 0.002
3 Systolic shear stress, dyne/cm2
 Baseline 0.10±0.03 0.002 0.12±0.04 0.006 0.02 0.002±0.001 0.023 0.003±0.001 <.0001 0.04
 Hyperemic 0.03±0.02 0.07 −0.03±0.02 0.17 −0.001±0.001 0.29 −0.002±0.000 <.0001
4 Mean shear stress, dyne/cm2
 Baseline −0.06±0.17 0.74 0.17±0.15 0.25 0.01 −0.003±0.003 0.26 0.002±0.003 0.54
 Hyperemic −0.06±0.03 0.072 −0.06±0.03 0.036 −0.002±0.001 0.003 −0.002±0.001 0.003 0.02
5 Log FVR, resistance units
 Baseline 1.82±1.00 0.068 −1.81±1.19 0.13 0.01 0.03±0.02 0.11 −0.013±0.02 0.51 0.003
 Hyperemic 5.97±1.47 <.0001 3.89±1.86 0.036 0.12±0.03 <.0001 0.02±0.03 0.44
6 Baseline baD, mm 0.05±0.08 0.47 0.05±0.08 0.49 0.001 0.002±0.002 0.32 0.002±0.001 0.051 0.01
7 Log (baFMD+10) −2.39±2.57 0.35 −1.76±1.87 0.35 0.002 −0.10±0.05 0.039 −0.09±0.04 0.011 0.01
8 baNMD, % −0.36±0.09 0.0001 −0.25±0.07 0.0002 0.04 −0.01±0.002 0.002 −0.004±0.001 0.008 0.02
*

Models 1–8 are adjusted for other independent predictors of pulse pressure and aPWV (Table 3); Model 5 (for FVR) did not include mean arterial pressure as a covariate. Only summaries for brachial reactivity measures are shown; associations of other variables with pulse pressure and aPWV after adding vasoreactivity variables were not different from those in Table 3. For each model, ΔR2 represents change in R2 after adding the corresponding brachial vasoreactivity measure(s) to the respective multivariable model in Table 3. Abbreviations as in Table 2.