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. 2010 May;185(1):313–326. doi: 10.1534/genetics.109.112532

TABLE 3.

Comparison of the influence of the approximation on the power of LBF for simple models with different migration schemes

Evidence Counts (based on Inline graphic, Inline graphic, and LBFHM)
Model 1a 1b 2a 2b
Nm 1250 0.25 0.0025
Approximation 16 4 H 16 4 H 16 4 H 16 4 H
    Against M0 0 5 26 0 8 29 70 49 53 100 100 78
    Against M1 100 94 73 100 92 71 30 51 47 0 0 22

LBF compared a full model (model M1 = □⇆▪) with a panmictic population (model M0 = Inline graphic). Models used to simulate the data were as follows: 1a, a single population, the sampled individuals split randomly into two sets (Inline graphic); 1b, two populations exchanging many migrants (Nm = 1250); 2a, two populations exchanging a moderate number of migrants (Nm = 0.25); and 2b, two populations with very low migration rate (Nm = 0.0025). The marginal likelihoods used in the LBF were approximated with thermodynamic integration (TI) with 16 and 4 scaler bins and with the harmonic mean (HM4).