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. Author manuscript; available in PMC: 2010 May 14.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Jan 23;19(13):3686–3692. doi: 10.1016/j.bmcl.2009.01.057

Figure 2. Cell-based analysis of novel PDE4 inhibitors.

Figure 2

Effect of PDE4 inhibition by 1, 5, 10 and 18 in a cell-based cyclic nucleotide-gated cation channel biosensor assay. Specific EC50 values are as follows; (A) EC50 for 1 = 131.5 nM. (B) EC50 for 5 = 18.7 nM. (C) EC50 for 10 = 2.3 nM. (D) EC50 for 18 = 34.2 nM. The data represents the results from four separate experiments.