Figure 6.

Synergism between fibrinogen and active TGF-β in the induction of astrogliosis and neurocan deposition. A, Fib ^−/− mice show reduced astrogliosis and neurocan expression demonstrated by immunostaining for GFAP and neurocan, 3 d after TGF-β injection followed by SWI. Uninjured WT mice served as controls. Stereotactic injection of TGF-β induced a similar increase in astrogliosis and neurocan expression in Fib ^−/− and WT controls injected with ACSF. B, Quantification revealed significant lower levels of GFAP and neurocan in Fib ^−/− mice than in WT mice (n = 4 per group) after TGF-β injection and SWI. Values are mean ± SEM. *p < 0.001. Scale bar, 90 μm.