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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Neuron. 2010 Apr 15;66(1):15–36. doi: 10.1016/j.neuron.2010.01.018

Figure 8. Transcriptional control of photoreceptor diversification.

Figure 8

A. Regulation of photoreceptor subtype identity in the mouse retina. Nrl and Nr2e3 promote rod development and repress cone cell programs in rods. These transcription factors also regulate photoreceptor subtype-specific expression of opsins in rods and are likely to regulate other genes controlling rod and cone cell development (adapted from Onishi et al. 2009).

B. Regulation of photoreceptor subtype in fly retina. NFYC represses R8 development in R7 by preventing Senseless expression. Senseless regulates R8 and R7 subtype-specific opsin expression and has also been implicated in expression of Capricious and other genes regulating R8 targeting. Prospero also regulates opsin expression and acts in parallel with other transcription factors to regulate R7 targeting. R7 and R8 subtypes can be further divided by the opsins they express (see text).