Table 3. Rate of hospitalization due to infectious disease and rate of death with infection among biological and adoptive siblings, in predisposed siblings compared to non-predisposed.
| HR (95% CI) | Hospitalization of siblings | Mortality of diseased siblings | |
| Given predisposition to infection1 | Given predisposition to contract infection2 | Given predisposition to death with infection3 | |
| Full siblings | 1.26 (1.01–1.57) | 1.76 (0.78–3.98) | 9.36 (2.94–29.8) |
| Paternal half siblings | 1.10 (0.97–1.25) | 1.18 (0.65–2.14) | 0.78 (0.21–2.96) |
| Maternal half siblings | 1.04 (0.92–1.18) | 1.19 (0.63–2.28) | 0.94 (0.27–3.33) |
| Biological siblings combined4 | 1.18 (1.03–1.36) | 1.53 (0.86–2.74) | -5 |
| Adoptive siblings | 1.23 (0.98–1.53) | 1.12 (0.50–2.53) | 0.76 (0.06–9.87) |
Analyses are stratified by sex of adoptee and sibling, and by birth year group of adoptee and sibling. Siblings of the same adoptee are analysed in one model allowing for correlation between observations.
1
Siblings to an adoptee hospitalized with infection or with infection as a cause of death.
2
Siblings to an adoptee hospitalized with infection.
3
Siblings to an adoptee with infection as a cause of death.
4
Assuming additive genetic effect on the log hazard scale.
5
Assuming additive genetic effect is inappropriate.