Table 1. Evolutionary conserved gene pairs.
| No. Org | No. Gene pairs | Evol. Cons. | GS2 score | GO | Gene 1 description | Gene 2 description | Func. Rel. | Phylum |
| 9 | 9 | 1.13 | 0.80 | * | 40S ribosomal protein S16 | 60S ribosomal protein L13 | ✓ | Fc Fm Fs Ft Pr |
| 24 | 68 | 0.95 | 0.63 | * | Histone H2B | Histone H2A | ✓ | Fb Fc Fp Fs Ft Fz M |
| 8 | 24 | 0.75 | 0.84 | * | ATP-binding cassette sub-family A | ATP-binding cassette sub-family A | ✓ | Fc H M V Pr |
| 19 | 21 | 0.64 | 0.00 | 60S ribosomal protein L21 | 40S ribosomal protein S9 | ✓ | Fb Fc Fp Fz | |
| 12 | 14 | 0.60 | 0.75 | * | Probable pyridoxine biosynthesis protein SNZ1 | Probable glutamine amidotransferase SNO1 | ✓ | Fp Fs M Pr |
| 17 | 17 | 0.56 | 0.38 | * | DNA replication licensing factor MCM2 | Protein mlo2 | Fp Fs Ft | |
| 16 | 16 | 0.56 | 0.00 | Putative Xaa-Pro aminopeptidase - Uncharacterized peptidase C22G7.01c | Importin beta-like protein kap111 - Pleiotropic drug resistance regulatory protein 6 - Tryptophanyl-tRNA synthetase, mitochondrial | Fp Fs Ft | ||
| 17 | 17 | 0.55 | 0.25 | * | Eukaryotic initiation factor 4A-III | Pre-mRNA-splicing factor PRP9 | Fb Fc Fp | |
| 9 | 9 | 0.55 | 1.00 | * | Chitin synthase | Chitin synthase | ✓ | Fp H |
| 4 | 19 | 0.54 | 0.62 | * | Histone H2B | Histone H2A | ✓ | Fs M V |
| 16 | 21 | 0.49 | 0.80 | * | Histone H4 | Histone H3 | ✓ | Fp Fs Ft |
| 12 | 12 | 0.48 | 0.10 | * | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase | U3 small nucleolar RNA-associated protein 21 - Uncharacterized WD repeat-containing protein C1672.07 | Fp Fs Ft | |
| 11 | 11 | 0.48 | 0.30 | * | Uncharacterized protein C11G11.07 - mRNA transport regulator MTR10 | Probable small nuclear ribonucleoprotein E | Fb Fp Fs Ft | |
| 15 | 15 | 0.47 | 0.27 | * | Pre-mRNA-splicing factor SYF1 | Vacuolar proton pump subunit D | Fp Fs | |
| 14 | 14 | 0.46 | 0.00 | * | 60S ribosomal protein L11 | Small nuclear ribonucleoprotein-associated protein B | Fb Fp Ft | |
| 14 | 14 | 0.46 | 0.22 | * | Ribosome biogenesis protein RLP24 | Mitochondrial import inner membrane translocase subunit TIM14 | Fp Fs | |
| 17 | 17 | 0.46 | 0.13 | * | ATP-dependent rRNA helicase RRP3 | Brix domain-containing protein C1B9.03c - Ribosome biogenesis protein SSF1 | Fp Fs | |
| 13 | 13 | 0.45 | 0.00 | Uncharacterized protein | Uncharacterized protein | Fp Fs | ||
| 14 | 14 | 0.45 | 0.43 | * | U3 small nucleolar RNA-associated protein 17 | DNA-directed RNA polymerases I, II, and III subunit RPABC5 | Fp Fs Ft | |
| 2 | 3 | 0.45 | 0.12 | * | Protein kinase gsk3 | Guanosine-diphosphatase | Fm Fz | |
| 12 | 16 | 0.44 | 0.80 | * | Iron transport multicopper oxidase FET precursor | Iron transporter FTH1 - Plasma membrane iron permease | ✓ | Fb Fc Fp Ft Fz |
| 12 | 17 | 0.43 | 0.09 | * | Alpha-glucosidase | Alpha-glucosides permease MPH2/3 | Fb Fp Fs | |
| 7 | 7 | 0.43 | 0.62 | * | Homogentisate 1,2-dioxygenase | Fumarylacetoacetase | Fp H | |
| 15 | 15 | 0.42 | 0.60 | * | Palmitoyltransferase ERF2 | Uncharacterized protein C3H7.08c | Fp Ft | |
| 15 | 15 | 0.42 | 0.47 | * | Protein CASP | Vacuolar protein sorting-associated protein 3 | Fp Ft | |
| 15 | 15 | 0.42 | 0.45 | * | Eukaryotic translation initiation factor 5A-1,2 | Vacuolar protein sorting-associated protein 52 | Fp Ft | |
| 15 | 15 | 0.42 | 0.11 | * | Vacuolar protein-sorting-associated protein 24 | Protein wos2 | Fp Ft | |
| 15 | 15 | 0.42 | 0.00 | Uncharacterized WD repeat-containing protein | RNA processing protein efg1 | Fp Ft | ||
| 15 | 15 | 0.42 | 0.00 | Regulator of ribosome biosynthesis | 37S ribosomal protein S23, mitochondrial | Fp Ft | ||
| 4 | 4 | 0.41 | 0.19 | * | Pre-mRNA-splicing factor CWC24 (Complexed with CEF1 protein 24) | Co-chaperone protein HscB, mitochondrial precursor | Fs V | |
| 14 | 14 | 0.41 | 0.09 | * | Actin-related protein 2/3 complex subunit 4 | Ubiquitin carboxyl-terminal hydrolase 6 | Fp Ft | |
| 12 | 12 | 0.41 | 0.30 | * | ATP-dependent RNA helicase DBP5 | Uncharacterized protein C12C2.05c | Fp Ft | |
| 14 | 14 | 0.40 | 0.91 | * | DNA repair protein RAD16 | DNA repair protein RAD7 | ✓ | Fp Ft |
| 13 | 13 | 0.40 | 0.35 | * | Calcineurin subunit B | Enhancer of polycomb-like protein 1 | Fp Ft | |
| 15 | 15 | 0.40 | 0.24 | * | DNA-directed RNA polymerase III subunit RPC3 | Cytochrome b-c1 complex subunit 2, mitochondrial precursor | Fp Fs | |
| 14 | 14 | 0.40 | 0.69 | * | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | Transcription factor IIIA | ✓ | Fp Fs |
| 11 | 11 | 0.40 | 0.00 | * | Cullin-3 | Uncharacterized protein C24H6.02c | Fp Ft | |
| 13 | 13 | 0.40 | 0.51 | * | Serine/threonine-protein kinase chk1 | Ubiquitin-conjugating enzyme E2-20 kDa | Fp Ft | |
| 13 | 13 | 0.40 | 0.24 | * | Eukaryotic peptide chain release factor GTP-binding subunit | Ran-specific GTPase-activating protein 30 | Fp Ft | |
| 10 | 10 | 0.40 | 0.00 | Protein pdh1 precursor - Uncharacterized membrane protein YOL107W | Uncharacterized WD repeat-containing protein C1235.09 | Fp Ft | ||
| 12 | 12 | 0.39 | 0.53 | * | Elongation of fatty acids protein 2 | Cytochrome c oxidase polypeptide VI, mitochondrial precursor | Fp Ft | |
| 13 | 13 | 0.39 | 0.00 | Probable 60S ribosomal protein L28e | UPF0357 protein C1687.07 precursor | Fp Ft | ||
| 10 | 10 | 0.39 | 0.27 | * | Geranylgeranyl transferase type-2 subunit alpha | Meiosis-specific APC/C activator protein AMA1 | Fp Ft | |
| 14 | 14 | 0.39 | 0.71 | * | 60 kDa heat shock protein, mitochondrial precursor | 10 kDa heat shock protein, mitochondrial precursor | ✓ | Fb Fc M |
| 8 | 12 | 0.39 | 0.00 | Beta-1,3-glucan-binding protein precursor | Fb Fp Fs | |||
| 6 | 6 | 0.39 | 0.00 | 40S ribosomal protein S15 | 60S acidic ribosomal protein P2-beta | ✓ | Fb Fs Ft | |
| 13 | 16 | 0.38 | 1.00 | * | 3-oxoacyl-(acyl-carrier-protein) synthase | S-acyl fatty acid synthase thioesterase | ✓ | Fb Fp |
| 2 | 2 | 0.38 | 0.00 | Vesicle associated membrane protein | DNA excision repair protein ERCC-1 | V Pr | ||
| 12 | 12 | 0.38 | 0.42 | * | Histone deacetylase | Chromatin modification-related protein YNG2 | Fp Ft | |
| 11 | 11 | 0.38 | 0.23 | * | Biotin ligase | Mitochondrial genome maintenance protein MGM101, mitochondrial precursor | Fp Ft | |
| 3 | 4 | 0.38 | 0.65 | * | ATP synthase subunit beta, mitochondrial precursor | ATP synthase subunit delta, mitochondrial precursor | ✓ | Fc Fz H |
Gene pairs are ordered according to evolutionary conservation. First column shows the number of species where a particular gene pair is present. Second column shows the total count of the gene pair in all species where it occurs. A star (*) indicates that both genes in a pair have a GO annotation. Functional relationships were inferred by mining of literature. Fp, Pezizomycotina; Fs, Saccharomycotina; Ft, Thaphrinomycotina; Fb, Basidiomycota; Fc, Chytridiomycota; Fm, Microsporidia; M, Mammals; V, Viridiplantae; Pr, Protozoa; H, Heterokonta.