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. 2010 Apr 16;11(4):1808–1824. doi: 10.3390/ijms11041808

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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 2. — The Bcl-2 family of proteins and their mode of action. (a) The Bcl-2 family is split by structure and sequence into two groups: the multi-motif proteins that includes both pro-survival (Bcl-2, Bcl-x_L, Bcl-w, Mcl-1, A1, Bcl-B) and pro-apoptotic members (Bax, Bak, Bok) that have an all helical Bcl-2 fold with IDRs and the IDP BH3-only proteins that only have a single BH3 motif (Bim, Bad, Bmf, Bid, Puma, Bik, Noxa, Hrk). The colored bars indicate the extent of helices and the location of BH motifs is indicated by black bars (b) Scheme showing the mode of Bcl-2 family action. The BH3-only proteins inhibit the pro-survival action allowing the Bax-like proteins to permeablize the mitochondrial outer membrane releasing cytochrome c to activate the caspase cascade that destroys the cell.