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. 2010 Apr 16;11(4):1808–1824. doi: 10.3390/ijms11041808

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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 4. — Close-up view of differences between the A1 and Mcl-1 grooves. (a) The presence of a basic patch provided by residues R214 and K215 in the α3-α4 loop in Mcl-1 accommodates the presence of an acidic residue (E74) in the BH3 domain of mouse NoxaB (PDB: 2NLA) [27]. (b) The same view of the Mcl-1:NoxaA complex (PDB: 2ROC) where a hydrophobic residue (F23) occupies a similar position to E74 in (a). (c) An acidic patch formed by residues D57 and D58 occupies the structurally equivalent position in A1 (PDB: 2VOF) to the basic patch in Mcl-1. NoxaB does not bind A1 [26]. The ribbon of the BH3 ligand is colored yellow. Basic residues are shown in blue and acidic residues in red.