Table 2.

Blood glucose, insulin and intact proinsulin levels at baseline and 3 months after treatment with insulin GLA or NPH insulin.

			Breakfast			Lunch			Dinner
			0′	60′	120′	0′	60′	120′	0′	60′	120′
Glucose (mg/dl)	NPH	Baseline	156 ± 34	217 ± 44	204 ± 41	141 ± 34	158 ± 41	140 ± 32	100 ± 16	145 ± 33	147 ± 37
		3 months	119 ± 29*	197 ± 28	183 ± 38	136 ± 38	163 ± 36	146 ± 28	108 ± 15	156 ± 21	154 ± 21
	GLA	Baseline	158 ± 19	233 ± 27	211 ± 29	131 ± 28	142 ± 26	131 ± 20	102 ± 16	147 ± 18	148 ± 19
		3 months	121 ± 23*	200 ± 29	181 ± 28*	117 ± 24	160 ± 23	151 ± 23	108 ± 19	159 ± 21	158 ± 26
Insulin (mU/l)	NPH	Baseline	18.6 ± 11.3	56.2 ± 22.2	64.0 ± 25.5	39.6 ± 20.7	52.3 ± 22.5	46.6 ± 17.6	24.0 ± 16.9	35.8 ± 19.1	39.5 ± 22.3
		3 months	20.0 ± 9.6	46.8 ± 20.7*	51.6 ± 27.5*	33.0 ± 16.7	42.5 ± 15.6*	33.2 ± 13.7*	17.6 ± 9.3*	28.9 ± 11.9*	29.0 ± 10.8*
	GLA	Baseline	14.7 ± 8.3	55.5 ± 27.7	66.7 ± 43.1	42.4 ± 23.2	44.3 ± 21.2	38.8 ± 30.4	17.5 ± 8.8	28.0 ± 13.1	31.2 ± 15.2
		3 months	19.4 ± 7.8*	44.9 ± 16.7	49.8 ± 24.8	24.6 ± 11.1*	36.9 ± 15.7	31.5 ± 13.7	16.2 ± 6.2	25.7 ± 9.3	26.7 ± 8.9
Proinsulin (pmol/l)	NPH	Baseline	20.5 ± 12.7	33.3 ± 20.5	48.3 ± 27.3	47.6 ± 27.4	54.4 ± 31.4	57.5 ± 33.4	38.5 ± 24.7	41.1 ± 22.8	45.2 ± 26.9
		3 months	7.2 ± 6.3*	13.5 ± 9.5*	23.1 ± 13.0*	22.3 ± 13.7*	25.5 ± 14.7*	24.4 ± 14.2*	15.0 ± 11.4*	17.8 ± 12.0*	20.2 ± 12.5*
	GLA	Baseline	16.5 ± 6.1	27.1 ± 7.5	44.9 ± 15.6	48.9 ± 12.9	48.6 ± 14.7	48.0 ± 16.6	29.7 ± 10.4	31.4 ± 11.0	36.4 ± 11.9
		3 months	5.7 ± 2.8*	12.8 ± 5.8*	23.1 ± 13.0*	17.7 ± 7.9*	20.1 ± 9.1*	20.7 ± 6.7	10.6 ± 5.3*	12.5 ± 5.7*	14.5 ± 5.9*

Mean ± standard deviation. GLA, glargine.

^*p < 0.05 at 3 months vs. baseline.